Welcome to Grace Hospital. The toughest surgical residency program west of Harvard is a brutal training ground for the newest medical recruits. Meet Meredith, Izzie, George, Alex and Cristina. Yesterday they were students. Today they are doctors. And if they can make it through seven years of the finest hell Grace has to offer, they will be surgeons. But the rest of life doesn't stop just because their residency is tough, so this group will also have to deal with jealous boyfriends and sick parents, one night stands and housing crises, with only each other to rely on.